Table 2.

The top ten upregulated and top ten downregulated miRNAs in MV+ patients compared to MV− patients in the discovery sample using NGS.

	Chr	Start	End	logFC MV+ vs MV−	p value MV+ vs MV−
Downregulated miRNAs
hsa-miR-144-3p	chr17	28,861,548	28,861,567	− 1.952	0.011
hsa-miR-15a-3p	chr13	50,049,130	50,049,151	− 1.941	0.003
hsa-miR-374a-3p	chrX	74,287,295	74,287,316	− 1.886	0.002
hsa-miR-181c-5p	chr19	13,874,725	13,874,746	− 1.849	0.001
hsa-miR-374a-5p	chrX	74,287,325	74,287,346	− 1.831	0.004
hsa-miR-1277-5p	chrX	118,386,401	118,386,424	− 1.795	0.004
hsa-miR-369-3p	chr14	101,065,641	101,065,661	− 1.783	0.005
hsa-miR-146a-3p	chr5	160,485,408	160,485,429	− 1.761	0.011
hsa-miR-556-3p	chr1	162,342,600	162,342,621	− 1.746	0.007
hsa-miR-16-1-3p	chr13	50,048,985	50,049,006	− 1.716	0.009
Upregulated miRNAs
hsa-miR-193b-5p	chr16	14,303,980	14,304,001	2.650	0.001
hsa-miR-4669	chr9	134,379,449	134,379,470	2.512	0.009
hsa-miR-193a-5p	chr17	31,560,016	31,560,037	2.168	0.0001
hsa-miR-4697-3p	chr11	133,898,506	133,898,529	1.957	0.048
hsa-miR-4516	chr16	2,133,120	2,133,136	1.955	0.002
hsa-miR-1228-3p	chr12	57,194,555	57,194,574	1.932	0.007
hsa-miR-3182	chr16	83,508,349	83,508,365	1.862	0.0005
hsa-miR-150-3p	chr19	49,500,797	49,500,818	1.826	0.005
hsa-miR-885-3p	chr3	10,394,499	10,394,520	1.753	0.019
hsa-miR-34c-3p	chr11	111,513,484	111,513,505	1.690	0.018

miRNA name: Annotations related to the gene (miRNA) according to miRBase v22.1, genome version GRCh38. p value obtained with the moderated t-test.

Chr chromosome, logFC log2 fold change, MV mechanical ventilation requirement.