Substrate scope for the syntheses of substituted benzo[d]imidazo[2,1-b]thiazoles 3.

Entry	R1	(C6H5)R2	Yielda	LRMSb	H-bond donor	H-bond acceptor	clog Pc
3a	H	C6H5	95	250	0	2	4.86
3b	H	4-(C6H5)CH3	94	264	0	2	5.36
3c	H	4-(C6H5)OCH3	93	280	0	3	4.87
3d	H	–CO2Et	95	246	0	4	2.94
3e	H	4-(C6H5)CN	96	275	0	3	4.29
3f	H	4-(C6H5)–CF3	92	318	0	2	5.74
3g	H	4-(C6H5)NO2	90	295	0	3	4.60
3h	7-OEt	4-(C6H5)CH3	94	308	0	3	5.90
3i	7-OEt	4-(C6H5)–CF3	94	362	0	3	6.28
3j	7-OEt	2,4-(C6H5)(F)2	92	330	0	3	5.69
3k	7-NO2	C6H5	90	295	0	4	4.61
3l	7-NO2	4-(C6H5)CF3	92	363	0	4	5.50

^aIsolated yields.

^bLMRS was recorded by using the GC-MS method.

^cclog P estimated by using by ChemBioOffice 2010.