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. 2020 Jan 3;10(2):770–778. doi: 10.1039/c9ra08929b

Substrate scope for the synthesis of N-alkylated 2-amino benzo[d]oxazoles 5.

graphic file with name c9ra08929b-u3.jpg
Entry R1 (C6H5)R2 Yielda LRMSb H-bond donor H-bond acceptor clog Pc
5a H C6H5 94 253 1 4 −0.39
5b H 4-(C6H5)OCH3 93 283 1 5 −0.17
5c H 4-(C6H5)CI 94 287 1 4 0.39
5d H 4-(C6H5)CF3 94 321 1 4 0.62
5e H 2,4-(C6H5)(F)2 92 289 1 4 −0.45
5f 5-CI 4-(C6H5)OCH3 93 317 1 5 0.39
a

Isolated yields.

b

LRMS was recorded by using the GC-MS method.

c

clog P estimated by using by ChemBioOffice 2010.