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. 2022 Apr 7;145(18):1398–1411. doi: 10.1161/CIRCULATIONAHA.121.057888

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© 2022 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 1. — Genomic meta-analysis scan of plasma ACE2. Mapped genes are labeled at genome-wide significant loci (P<5×10⁻⁸). Genome-wide significant variants with minor allele frequency <0.05 are marked as circles instead of solid dots. Illustrations are provided for the interactions between 2 pairs of mapped loci; the locus on chromosome 16 is a transcription binding site for the transcription factor HNF4A mapped on chromosome 20, and HNF1A acts as the transcription factor for the ACE2 gene. ACE2 indicates angiotensin-converting enzyme 2; and TFBS, transcription factor binding site.