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. 2022 Apr 7;145(18):1398–1411. doi: 10.1161/CIRCULATIONAHA.121.057888

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© 2022 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 2. — Genetic correlations between plasma ACE2 and human complex traits and diseases. A, Statistically significant (false discovery rate <5%) genetic correlations with ACE2 (angiotensin-converting enzyme 2) are shown; severe COVID-19, C-reactive protein (CRP), and other representative traits are labeled. Error bars represent SEs. Colors label different groups of phenotypes. Detailed explanations of the annotated phenotypes are given in the Supplemental Material. B, Enrichment of genetic correlations with ACE2 within each group of phenotypes. Circles are the quantile-quantile (QQ) plots of the genetic correlations test statistics against the null, whereas the solid dots are the QQ plots of the test statistics within each phenotype group against all the analyzed phenotypes. BMI indicates body mass index; FVC, forced vital capacity; and SBP, systolic blood pressure.