Table 2. Top 20 Abundant Proteins in the Corona Ranked by the Summed Peptide Ion Intensity Identified by Mass Spectrometry^a.

silica corona					full plasma32
no.	intensity (log2)	Uniprot identifier	protein names	MW (kDa)	protein names	concn (μg/mL)
1	37.3	P02647	Apolipoprotein A-I	30.78	Albumin	4.0 × 104
2	36.8	P02679	Fibrinogen gamma chain	49.50	Immunoglobulin heavy constant gamma 1	1.1 × 104
3	36.8	P02675	Fibrinogen beta chain	55.93	Transferrin	2.3 × 103
4	36.2	P02671	Fibrinogen alpha chain	94.97	Immunoglobulin heavy constant alpha 1	2.0 × 103
5	33.8	P04114	Apolipoprotein B-100	515.6	Apolipoprotein A-I	1.4 × 103
6	33.2	P04196	Histidine-rich glycoprotein	59.58	Alpha-2-macroglobulin	1.4 × 103
7	32.6	P01042	Kininogen-1	71.96	Alpha-1-antitrypsin	1.1 × 103
8	32.5	P02649	Apolipoprotein E	36.15	Complement C3	9.5 × 102
9	32.1	P06727	Apolipoprotein A-IV	45.37	Haptoglobin	8.8 × 102
10	31.7	P02751	Fibronectin	246.69	Immunoglobulin heavy constant mu	8.0 × 102
11	31.5	P02768	Albumin	69.37	Hemopexin	7.5 × 102
12	31.4	P01024	Complement C3	187.15	Apolipoprotein B-100	7.2 × 102
13	31.1	P00748	Coagulation factor XII	67.79	Fibrinogen gamma chain	6.7 × 102
14	30.8	D6R934	Complement C1q subcomponent subunit B	26.46	Alpha-2-HS-glycoprotein	6.3 × 102
15	30.6	A0A4W9A917	Immunoglobulin heavy constant gamma 3 (Fragment)	41.22	Alpha-1-acid glycoprotein 2	6.1 × 102
16	30.4	K7ERI9	Apolipoprotein C-I (Fragment)	8.65	Complement factor H	5.0 × 102
17	30.2	P02747	Complement C1q subcomponent subunit C	25.77	Interalpha-trypsin inhibitor	5.0 × 102
18	30.2	P27169	Serum paraoxonase/arylesterase 1	39.73	Alpha-1-antichymotrypsin	4.5 × 102
19	30.1	P05155	Plasma protease C1 inhibitor	49.76	Ceruloplasmin	4.0 × 102
20	29.8	A0A096LPE2	SAA2-SAA4 readthrough	23.35	Vitamin D-binding protein	4.0 × 102

^aFor comparison, the top abundant proteins from full plasma are also shown.³⁵ Corona proteins carrying N-glycans registered in the Uniprot database are bolded (accessed June 16, 2021; https://www.uniprot.org/).