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. 2022 Apr 14;9:866343. doi: 10.3389/fmed.2022.866343

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Copyright © 2022 Hasan Khudhair, Al-Gareeb, Al-kuraishy, El-Kadem, Elekhnawy, Negm, Saber, Cavalu, Tirla, Alotaibi and Batiha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of vitamin C and curcumin pretreatment alone and in combination on (A) MDA tissue level, (B) SOD activity, and (C) GSH tissue level (a) MTX compared to the control P < 0.05, (b) vitamin C or curcumin compared to MTX P < 0.05, (b,c) combination VC and CUR compared to VC or CUR alone P < 0.05, (b–d) combination VC and CUR compared to VC or CUR alone P < 0.