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. 2022 Apr 14;9:866343. doi: 10.3389/fmed.2022.866343

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Copyright © 2022 Hasan Khudhair, Al-Gareeb, Al-kuraishy, El-Kadem, Elekhnawy, Negm, Saber, Cavalu, Tirla, Alotaibi and Batiha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of treatments on histopathological examination of the liver tissue: (A) liver section of control group showed normal hepatocytes. (H&E; ×40). (B) Liver section of MTX-treated group showed necrosis of hepatocytes (brown arrow), infiltration of the inflammatory cell (black arrow), and prominent cellular degeneration (H&E; ×40). (C) Liver section of mice pretreated with 100 mg/kg of VC showed slight sinusoidal dilation (arrow) with mild cellular degeneration (H&E; ×40). (D) Liver section of the group pretreated with 200 mg/kg of VC showed slight sinusoidal dilation (yellow arrow) (H&E; ×40). (E) Liver section of the group pretreated with 10 mg/kg of CUR showed hepatocyte necrosis (brown arrow), sinusoidal dilation (yellow arrow), and inflammatory cell infiltration (black arrow) (H&E; ×40). (F) Liver section of the group pretreated with 20 mg/kg of CUR showed cellular degeneration with mild infiltration of inflammatory cells (black arrow) (H&E; (×40). (G) Liver section of mice pretreated with VC and CUR showed slight inflammatory cell infiltration (black arrow), necrotic cells (brown arrow), and slight congestion (red arrow) (H&E; ×40).