. 2022 Apr 14;9:866343. doi: 10.3389/fmed.2022.866343

TABLE 1.

Changes in serum liver enzyme between mice treated with MTX, vitamin C, and curcumin alone and in combination (pretreatment groups).

Groups	Parameters assessed
	ALT (IU/L)	AST (IU/L)	ALP (IU/L)	LDH (ng/mL)
Control	33.42 ± 1.92	27.42 ± 3.15	267.28 ± 15.63	21.83 ± 1.20
MTX	50.71 ± 3.67^a	34.71 ± 2.78^a	458 ± 34.91^a	38.48 ± 3.62^a
VC 100	30.28 ± 1.16^b	30.85 ± 1.51	200.91 ± 21.01^b	22.89 ± 1.53^b
VC 200	26.00 ± 3.54^b	26.14 ± 2.27^b	126.00 ± 11.85^b	18.40 ± 1.52^b
CUR 10	43.38 ± 3.16	31.23 ± 3.51	315.91 ± 31.21^b	12.7 ± 2.496^b
CUR 20	36.00 ± 2.54^b	28.34 ± 2.16^b	256.00 ± 13.5^b	11.66 ± 3.22^b
VC100 + CUR 10	27.63 ± 3.64^bd	27.48 ± 3.5^b	188.32 ± 18.5^bcd	10.82 ± 1.22^bc

Data are expressed as mean ± standard deviation (n = 7 per group). Significant difference vs. ^arespective control saline, ^brespective MTX group, ^crespective 100 mg/kg vitamin C group, ^drespective 10 mg/kg curcumin group, each at p<0.05.