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. 2022 Apr 14;13:853682. doi: 10.3389/fimmu.2022.853682

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Copyright © 2022 Furian, Russo, Zaza, Burra, Hartzell, Bizzaro, Di Bello, Di Bella, Nuzzolese, Agnolon, Florman, Rana, Lee, Kim, Maggiore, Maltzman and Cravedi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anti-viral IgG levels in kidney and liver transplant recipients after SARS-CoV-2 vaccination. Serum samples were collected at the time of the first (T0) and the second (T1) mRNA SARS-CoV-2 vaccine administration, and at 3 weeks after the second dose (T2). (A) Serological response of individual subjects against each of the tested viral antigens. Level considered positive is indicated by dotted horizontal lines for each antibody specificity. (B) Levels of IgG anti-RBD in kidney (blue) and liver (red) kidney transplant recipients at each time point. (C) Analyses shown in panel B were repeated after stratifying patients based on anti-RBD antibody response (MFI threshold for positivity: 8880). Horizontal lines represent 95 percent confidence intervals. *P < 0.05, **P < 0.01. MFI, Mean Fluorescence Intensity.