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. 2022 Apr 14;13:853682. doi: 10.3389/fimmu.2022.853682

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Copyright © 2022 Furian, Russo, Zaza, Burra, Hartzell, Bizzaro, Di Bello, Di Bella, Nuzzolese, Agnolon, Florman, Rana, Lee, Kim, Maggiore, Maltzman and Cravedi

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anti-spike IFN-γ+ T cell responses in kidney and liver transplant recipients after SARS-CoV-2 vaccination. (A) Anti-spike IFN-γ+ T cell spots of individual subjects (natural logarithmic scale). (B) Number of spots of anti-S IFN-γ FluoroSpot in kidney (blue) and liver (red) transplant recipients at each time point. (C) Analyses shown in panel B were repeated after stratifying patients based on anti-RBD antibody response (MFI threshold for positivity: 8880) (kidney and liver transplant recipients have been pooled together for this analysis). Horizontal lines represent 95 percent confidence intervals n.s., not significant; *P < 0.05, **P < 0.01.