Table 3.
Clinical outcomes.
| Overall cohort (n = 903) | VT ≤ 6 mL/kg PBW (n = 294) | VT > 6 mL/kg PBW (n = 609) | P valuea | |
|---|---|---|---|---|
| Mortality | ||||
| Mortality at day 28 | 257 (28.9) | 67 (23.1) | 190 (31.7) | 0.005 |
| Mortality at day 90 | 313 (37.9) | 93 (34.1) | 220 (39.8) | 0.024 |
| In hospital mortality | 300 (36.1) | 84 (31.3) | 216 (38.3) | 0.017 |
| ICU mortality | 291 (33.0) | 80 (27.9) | 211 (35.5) | 0.013 |
| Clinical ventilator outcomes | ||||
| Ventilator free days at day 28, days | 2.48 [0.00–16.00] | 4.96 [0.00–16.99] | 0.96 [0.00–15.96] | 0.175 |
| Duration of ventilation, days | 16.00 [9.04–28.02] | 15.04 [9.52–28.04] | 16.00 [9.04–28.00] | 0.782 |
| Length of hospital stay in survivors | 29.04 [20.04–43.03] | 30.00 [19.52–42.54] | 29.04 [20.04–43.02] | 0.986 |
| Length of ICU stay in survivor | 17.04 [11.00–29.00] | 16.04 [10.00–28.01] | 18.00 [11.01–30.03] | 0.405 |
| Successful extubation | 528 (58.9) | 181 (62.2) | 347 (57.4) | 0.191 |
| Reintubation | 117 (13.1) | 37 (12.8) | 80 (13.3) | 0.917 |
| Tracheostomy | 145 (16.2) | 47 (16.1) | 98 (16.3) | 1.000 |
| Pneumothorax | 8 (0.9) | 2 (0.7) | 6 (1.0) | 0.971 |
| Extrapulmonary outcomes | ||||
| Thrombotic event | 259 (28.7) | 97 (33.0) | 162 (26.6) | 0.056 |
| Acute kidney injury | 403 (44.8) | 131 (44.7) | 272 (44.8) | 1.000 |
| Renal replacement therapy | 163 (18.1) | 59 (20.1) | 104 (17.1) | 0.316 |
Data are median [quartile 25% - quartile 75%] or No (%). Percentages may not total 100 because of rounding.
a
P value is computed comparing patients receiving VT ≤ 6 mL/kg PBW versus VT > 6 mL/kg PBW.