TABLE 5.
Comparison of pharmacokinetics of single doses of (+)-calanolide A in fasted versus fed subjects
| Dose cohort (n) | Mean ± SEMa
|
||||
|---|---|---|---|---|---|
| Dose (mg/kg) | Cmax (ng/ml) | Tmax (h) | AUC (ng · h/ml) | CL/F (ml/min/kg) | |
| 400 mg | |||||
| All (12) | 5.4 ± 0.2 | 1,721 ± 222 | 3.5 ± 0.6 | 9,149 ± 1,273 | 14.3 ± 3.6 |
| Fasted (6) | 5.4 ± 0.3 | 1,725 ± 279 | 3.3 ± 1.0 | 8,708 ± 1,592 | 12.5 ± 2.7 |
| Fed (6) | 5.3 ± 0.3 | 1,716 ± 373 | 3.7 ± 0.8 | 9,590 ± 2,126 | 16.1 ± 6.9 |
| 600 mg | |||||
| All (12) | 8.6 ± 0.3 | 2,168 ± 296 | 4.4 ± 1.2 | 11,808 ± 1,096 | 16.5 ± 4.8 |
| Fasted (6) | 8.9 ± 0.5 | 2,868 ± 295 | 2.6 ± 0.7 | 13,301 ± 661 | 11.2 ± 0.8 |
| Fed (6) | 8.4 ± 0.3 | 1,468 ± 320 | 6.3 ± 2.2 | 10,315 ± 1,988 | 21.8 ± 9.5 |
a
t1/2 values could not be calculated.