TABLE 3.
Treatment of experimental endocarditis caused by E. faecalis EF91 with a human-like profile with ampicillin or teicoplanin alone or in combination with gentamicin given once or three times a day
| Treatment group | No. of animals that died/ total no. | Mean log CFU of vegetation/ ga (95% CI) |
|---|---|---|
| Control | 4/24 | 9.55 (9.23–9.87) |
| Ampicillinb | 3/15 | 7.25 (6.50–7.99)* |
| Ampicillin plus gentamicin, tidb | 2/15 | 5.23 (4.39–6.07)*† |
| Teicoplaninb | 3/18 | 6.66 (6.15–7.16)* |
| Teicoplanin plus gentamicin, tidb | 2/14 | 4.86 (4.09–5.63)*†‡ |
| Teicoplanin plus gentamicin, once dailyb | 2/14 | 5.07 (4.22–5.92)*†‡ |
a
Results show the mean log CFU of aortic vegetations per gram after 3 days of treatment. The 95% confidence interval (95% CI) is indicated in parentheses. *, P < 0.001 versus control; †, P < 0.01 versus ampicillin; ‡, P < 0.05 versus teicoplanin.
b
Ampicillin at 2 g/4 h given i.v. (H-L); teicoplanin at 10 mg/kg i.v. (H-L); gentamicin at 1 mg/kg/8 h i.v. (H-L) (gentamicin, t.i.d.); gentamicin at 4.5 mg/kg/24 h i.v. (H-L) (gentamicin, once daily).