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. 2022 Apr 14;10:832363. doi: 10.3389/fped.2022.832363

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Copyright © 2022 Zhang, Amat, Tang, Chen, Tian, Hu, Chen, Shen and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of the frequencies of variation at multiple sites of NUDT15 in different ethnic groups and the NUDT15 structural domain and protein structure. (A) *P < 0.05; **P < 0.01; ***P < 0.001. (B) The NUDT15 structural domain obtained from St. Jude Cloud is marked in color, and p.P46R (c.137C > G and c.138T > G) was located on the Nudix-Hydrolase-19 functional domain. (C) The position of p.P46R in the NUDT15 protein derived from Uniprot is highlighted in green.