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. 2022 Apr 14;13:881321. doi: 10.3389/fimmu.2022.881321

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Copyright © 2022 Song, Liu, Cao, Lu, Ren, Zheng, Ma, Hu, Lin, Li, Zheng and Chen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The gating strategy of CD8⁺ T cells populations and other markers. Lymphocytes and single cells were gated first. Then CD3⁺CD8⁺cells were gated. Central memory (TCM: CD45RA^-CCR7⁺), Tnaive (CD45RA⁺CCR7⁺), effector memory (TEM: CD45RA^-CCR7^-), and terminally differentiated effector (TEMRA: CD45RA⁺ CCR7^-) subsets were gated based on gated CD8⁺ cells. CD38 and HLA-DR were gated based on gated CD8⁺ cells and each subsets. CD107a, perforin, GranB, IFN-γ and IL-2 were gated based on gated CD8⁺ cells.