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. 2022 Apr 14;13:826164. doi: 10.3389/fimmu.2022.826164

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Copyright © 2022 Feola, Russo, Martins, Lopes, Vandermeulen, Fluhler, De Giorgi, Fusciello, Pesonen, Ylösmäki, Antignani, Chiaro, Hamdan, Feodoroff, Grönholm and Cerullo

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PeptiCRAd induced immune infiltration in distant not treated cancer lesions. (A) A representative gating strategy for the flow cytometry analysis of the untreated tumors is showed. (B–D) The immunological T cell profile was investigated in untreated lesions by flow cytometry. The frequency of CD8+ (B), of CD4+ (C) and CXCR3+ (CD8+) (D) T cells is shows. All the data are plotted as dot plot for each tumor and for each treatment group as mean± SEM. The significance was assessed by One way ANOVA and Tukey´s correction (ns P > 0.05, *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, P ≤ 0.0001).