Table 1.
Characteristics of included studies and patient populations stratified by donor type.
| Studies: Author, Year, Country | Study design | Arms | Sample size | Age, Years (mean ±SD) | Sex, No. Female (%) | MELD at Transplant (mean ± SD) | Diagnosis | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC | NASH | HCV/ HBV | ALD | PSC/ PBC/ AIH | |||||||
| Barbas, 2017, Canada28 | Retrospective study | LDLT | 48 | 54.7±9.4 | 13(27) | 17.8±8.7 | 8 | 48 | - | - | - |
| DDLT | 128 | 56.7±9.3 | 41(32) | 21.8±10.3 | 42 | 128 | - | - | - | ||
| Reichman, 2013, Canada29 | Matched cohort study | LDLT | 145 | 54.2±7.5 | 28(19.3) | 14.4±3.8 | 55 | 4 | 99 | 26 | 16 |
| DDLT | 145 | 53.9±7.7 | 28(19.3) | 14±6.8 | 80 | 4 | 99 | 26 | 16 | ||
| Chen, 2015, China63 | Retrospective study | LDLT | 66 | 45.8±7.7 | 6(9.1) | 11.1±4.5 | 66 | ||||
| DDLT | 163 | 47.9±9.5 | 19(11.7) | 12±6.4 | 163 | ||||||
| Lei, 2013, China64 | Retrospective study | LDLT | 31 | 44.4±9.7 | 13(41.9) | 9.3±6.1 | 31 | 28 | |||
| DDLT | 52 | 44±8.2 | 21(40.4) | 9.1±5.8 | 52 | 45 | |||||
| Li, 2011, China34 | Retrospective study | LDLT | 128 | 43±8.6 | 20(15.6) | 19.5±10.7 | 116 | 2 | 1 | ||
| DDLT | 221 | 44.5±9.7 | 42(19) | 18.2±9.6 | 209 | 5 | 5 | ||||
| Chok, 2017, China65 * | Retrospective study | LDLT | 54 | 51±12 | 12(22.2) | 40±1.3 | 1 | 43 | 1 | ||
| DDLT | 40 | 51±10.8 | 6(15) | 39±1.3 | 3 | 36 | |||||
| Liu, 2006, China43 * | Prospective study | LDLT | 124 | 47.5±8.3 | 27(21.8) | 21±6.5 | 36 | 111 | 1 | 3 | |
| DDLT | 56 | 48±9.8 | 12(21.4) | 19±10.8 | 11 | 49 | 0 | 1 | |||
| Wan, 2014, China37 | Matched cohort study | LDLT | 40 | 48.6±9.7 | 6(15) | 40 | 39 | ||||
| DDLT | 80 | 49.5±8.9 | 12(15) | 80 | 77 | 1 | 1 | ||||
| Chen, 2014, China66 | Matched cohort study | LDLT | 47 | 3(6.4) | 47 | ||||||
| DDLT | 94 | 6(6.4) | 94 | ||||||||
| Hu et al, 2015, China38 | Multi-center Retrospective study | LDLT | 389 | 48.1±8.7 | 29(7.5) | 389 | |||||
| DDLT | 6471 | 50.1±9.4 | 652(10.1) | 6471 | |||||||
| Bhangui, 2011, France36 | Retrospective study | LDLT | 36 | 54±7 | 4(11.1) | 13.5±5.9 | 36 | 28 | 6 | ||
| DDLT | 120 | 56±8 | 20(14.7) | 14.5±5.9 | 120 | 88 | 26 | ||||
| Schmeding, 2007, Germany67 | Retrospective study | LDLT | 20 | 55.7±8.9 | 7(35) | 11 | 20 | ||||
| DDLT | 269 | 51.4±9.8 | 105(39) | 73 | 269 | ||||||
| Kim, 2014, Korea68 | Retrospective study | LDLT | 21 | 53.1±10.3 | 7(33.3) | 13.1±5.4 | 17 | 18 | 3 | 0 | |
| DDLT | 29 | 51.3±9.2 | 14(48.3) | 24.9±11.6 | 11 | 14 | 6 | 3 | |||
| E. Kim, 2017, Korea69 | Retrospective study | LDLT | 109 | 52±8.5 | 28(26.6) | 12.5±8.3 | 68 | 93 | 19 | 1 | |
| DDLT | 76 | 53.2±11 | 26(34.2) | 24.9±11.7 | 16 | 40 | 21 | 4 | |||
| J.M. Kim, 2017, Korea70 * | Multi-center retrospective study | LDLT | 146 | 57±6.3 | 42(28.8) | 15±5.7 | 73 | 146 | |||
| DDLT | 35 | 53±8.8 | 11(31.4) | 21±10.5 | 11 | 35 | |||||
| Lee, 2012, Korea41 | Retrospective study | LDLT | 48 | 50±7.8 | 8(16.7) | 24.5±4.4 | 12 | 42 | 4 | ||
| DDLT | 23 | 48±12.9 | 10(43.5) | 23±3 | 6 | 16 | 2 | ||||
| Vigano’, 2008, Italy71 | Retrospective study | LDLT | 77 | 24 | 57 | ||||||
| DDLT | 244 | 75 | 143 | ||||||||
| Al Sebayel, 2015, Saudi Arabia72 * | Retrospective Study | LDLT | 222 | 53±10.8 | 83(37.4) | 18 | 45 | 120 | 24 | ||
| DDLT | 269 | 52±10.2 | 116(52.3) | 16 | 48 | 139 | 32 | ||||
| Jiang, 2013, China73* | Retrospective study | LDLT | 70 | 40.3±8.2 | 8(11.4) | 23.9±11.1 | 70 | ||||
| DDLT | 191 | 44.1±9.3 | 29(15.2) | 21.7±9.9 | 191 | ||||||
| SRTR, 2017, USA | Retrospective study | LDLT | 2750 | 51.9±12.3 | 1200(43.6) | 15±5.3 | 340 | 611 | |||
| DDLT | 58120 | 54.8±9.6 | 18120(31.2) | 21±9.9 | 12163 | 15673 | |||||
*
Denotes median to mean conversion or calculated SD