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Median and IQR of the DPV concentration in plasma (pg/mL), rectal fluid (ng/mg), and rectal tissue (ng/mg) after single and multiple doses of gel applied rectally. Horizontal gray dashed lines indicate the DPV assay LLOQ for each matrix (plasma 20 pg/mL, rectal fluid 0.01 ng/mg, and rectal tissue homogenate 0.003 ng/mg). DPV, dapivirine; IQR, interquartile range; LLOQ, lower limit of quantification. Color images are available online.
