Table 5.
Heritability estimates for the selected traits by EEG.
| Variable EEG |
CH | AG | RE | ||||||
|---|---|---|---|---|---|---|---|---|---|
| N# | h2 ± SE | P-value | N# | h2 ± SE | P-value | N# | h2 ± SE | P-value^ | |
| T2D | 517 | 0.30 ± 0.20 | 0.0466 | 530 | 0.82 ± 0.25 | 0.0003 | 500 | 0.46 ± 0.17 | 0.0028 |
| T2D_adjBMI@ | 517 | 0.29 ± 0.17 | 0.0455 | 530 | 0.83 ± 0.25 | 0.0002 | 500 | 0.48 ± 0.18 | 0.0024 |
| BMI | 517 | 0.53 ± 0.09 | 1.4 x 10-10 | 530 | 0.47 ± 0.09 | 3.1 x 10-10 | 500 | 0.44 ± 0.09 | 2.0 x 10-07 |
| WC | 517 | 0.51 ± 0.09 | 1.3 x 10-09 | 530 | 0.46 ± 0.10 | 1.9 x 10-09 | 500 | 0.61 ± 0.10 | 1.6 x 10-09 |
| HDL-C | 517 | 0.65 ± 0.09 | 2.9 x 10-16 | 530 | 0.71 ± 0.08 | 6.1 x 10-28 | 500 | 0.49 ± 0.09 | 4.0 x 10-10 |
| LDL-C | 517 | 0.36 ± 0.09 | 3.0 x 10-07 | 530 | 0.36 ± 0.08 | 2.3 x 10-10 | 500 | 0.49 ± 0.08 | 1.1 x 10-10 |
| TG | 517 | 0.37 ± 0.08 | 7.9 x 10-09 | 530 | 0.17 ± 0.10 | 0.0217 | 500 | 0.27 ± 0.11 | 0.0026 |
| TCHOL | 517 | 0.39 ± 0.08 | 1.4 x 10-08 | 530 | 0.36 ± 0.08 | 1.6 x 10-09 | 500 | 0.50 ± 0.09 | 6.2 x 10-11 |
| SBP | 517 | 0.31 ± 0.09 | 0.0001 | 530 | 0.39 ± 0.09 | 9.5 x 10-09 | 500 | 0.11 ± 0.10 | 0.1289 |
| DBP | 517 | 0.26 ± 0.10 | 0.0007 | 530 | 0.38 ± 0.08 | 4.6 x 10-11 | 500 | 0.13 ± 0.09 | 0.0578 |
| hs-CRP | 517 | 0.25 ± 0.09 | 4.9 x10-04 | 530 | 0.33 ± 0.09 | 1.0 x 10-06 | 500 | 0.17 ± 0.09 | 0.0156 |
| FG (non-T2D)$ | 348 | 0.43 ± 0.14 | 0.0004 | 334 | 0.86 ± 0.11 | 1.1 x 10-15 | 322 | 0.66 ± 0.11 | 2.3 x 10-09 |
| FI (non-T2D)$ | 348 | 0.81 ± 0.11 | 2.0 x 10-11 | 334 | 0.32 ± 0.13 | 0.0020 | 322 | 0.43 ± 0.15 | 0.0011 |
| HOMA-IR (non-T2D)$ | 348 | 0.74 ± 0.11 | 1.5 x 10-09 | 334 | 0.33 ± 0.13 | 0.0023 | 322 | 0.37 ± 0.15 | 0.0051 |
| HbA1c (non-T2D)$ | 348 | 0.39 ± 0.14 | 0.0016 | 330 | 0.64 ± 0.12 | 2.4 x 10-09 | 322 | 0.68 ± 0.13 | 1.0 x 10-07 |
#All quantitative traits were transformed using inverse normal transformation and adjusted for age and sex terms (i.e., age, sex, age x sex, age2, age2 x sex) if found to be significant for genetic analyses; @T2D (discrete trait) was analyzed with and without BMI as a covariate, in addition to age and sex terms as covariates; $Genetic analysis of glycemic traits were based on data from non-T2D individuals only; ^Heritability estimates that were not significant (i.e., P > 0.05) are shown in italics. For the purpose of comparison, h2 estimates for selected traits from SI are as follows: T2D = 54%, FG = 54%, HDL-C = 87% and LDL-C = 44%.