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HY6-F9 protects against further fentanyl challenges. One week after initial fentanyl challenge, rats (Fig. 1) were challenged with 0.2 mg/kg of fentanyl (s.c.), and monitored for (A) antinociception, (B) oxygen saturation, (C) heart rate, and (D) breath rate. At 30 minutes postfentanyl, fentanyl concentration was measured in (E) serum and (F) brain. Data are mean ± S.E.M. ****p<0.0001, ***p<0.001, **p<0.01, *p<0.05 relative to saline (control).
