Comparison of our protocols vs. reported methods for the preparation of 3aa.
| |||||
|---|---|---|---|---|---|
| Entry | Reagent system | Temp. (°C) | Time (h) | Yield (%) | Ref. |
| 1 | ArB(OH)2/Pd(OAc)2/phenanthroline/O2 | 100 | 20 | 85 | 5g |
| 2 | ArB(OH)2/Mn(OAc)2. | 120 | 12 | 80 | 5m |
| 3 | Ar2IBF4/Cs2CO3 | r. t. | 72 | 80 | 5i |
| 4 | ArNHNH2/PhIO | r. t. | 9 | 81 | 5j |
| 5 | ArNH2/t-BuONO/CH3SO3H | r. t. | 1.5 | 81 | 5k |
| 6 | ArNH2/t-BuONO | r. t. | 48 | 89 | 5l |
| 7 | ArN2BF4/Eosin-Y/blue LED | r. t. | 3 | 71 | 6 |
| 8 | ArNHNH2/K2S2O8 | 50 | 6 | 81 | This report |
| 9 | ArB(OH)2/K2S2O8/K2CO3 | 80 | 2 | 80 | This report |