Synthesis of Cu-MOF-catalysed 1,4-disubstituted-1,2,3-triazole derivatives^a.

Entry	R1	R2	Product	[Cu(INA)2(H2O)4]-complex		Cu(INA)2-MOF
				Time	Yieldb (%)	Time (h)	Yieldb (%)
1	PhCH2, 1a	Ph, 2a		12 min	93	4 min	95
2	1a	4-OMeC6H4, 2b		5 min	85	4 min	90
3	1a	4-MeC6H4, 2c		6 min	81	5 min	90
4	1a	1-Naphthyl, 2d		1 h	97	1 h	95
5	1a	4-NH2C6H4, 2e		10 min	70	10 min	96
6	4-OMeC6H4, 1b	2a		10 min	86	10 min	92
7	1b	2e		40 min	70	40 min	90
8	1b	2c		—	—	1 h	95
9	1a	PhCH2Se, 2f		2 h	80	2 h	86
10	1a	PhSe, 2g		1.5 h	96c	1.5 h	98
11	1a	PhSeCH2, 2h		12 h	50	12 h	70

^aReaction conditions: azide (0.5 mmol), acetylene (0.5 mmol), catalyst (1 mol%).

^bIsolated yield.

^cA mixture of 1 : 1.4 ratio of the 1,4- and 1,5-regioisomers determined by ¹H NMR spectroscopy.