Optimisation of Biginelli reaction^a.

#	Cu(INA)2 (mol%)	Time (h)	T (°C)	Yieldb (%)
1	[Cu(INA)2(H2O)4] complex (10)	2.5	100	90
2	[Cu(INA)2(H2O)4] complex (10)	2.5	80	88
3	[Cu(INA)2(H2O)4] complex (10)	2.5	50	25
4	[Cu(INA)2(H2O)4] complex (10)	2.5	r.t.	—
5	[Cu(INA)2(H2O)4] complex (10)	2.0	80	90
6	[Cu(INA)2(H2O)4] complex (10)	1.5	80	80
7	[Cu(INA)2(H2O)4] complex (5)	2.0	80	60
8	—	2.0	80	35
9	Cu(INA)2-MOF (10)	2.0	80	99

^aReaction conditions: urea (0.6 mmol), benzaldehyde (0.5 mmol), ethyl acetoacetate (1.0 mmol) and Cu(INA)₂ (10 mol%).

^bIsolated yield.