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. 2022 Apr 16;10(11):3321–3333. doi: 10.12998/wjcc.v10.i11.3321

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©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

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Some signals in the Wnt/β-catenin pathway by anti-signaling antibodies or intervening in their gene transcription to inhibit hepatocellular carcinoma growth. Using anti-signaling molecule antibodies or intervening in their gene transcription to inhibit Wnt/β-catenin pathway activation could suppress proliferation of hepatocellular carcinoma (HCC) cells or HCC growth. GPC-3: Glypican-3; HCC: Hepatocellular carcinoma; sCLU: Secretory clusterin; TCF: T-cell factor; SULF2: Sulfatase 2; pGSK3β: Phosphorylated glycogen synthase kinase 3β.