Fig. 5. Effect of collagen–curcumin nanocomposite on behavioral parameters like FT, SMA and grip strength for control (N), ischemic (I), ND1 (1 μg per kg b. wt), ND2 (10 μg per kg b. wt), ND3 (100 μg per kg b. wt) and free curcumin (FD) (100 μg per kg b. wt). The motor deficit was significant in the ischemic (I) group in comparison to the control (N) group. Treating the animals with nanocomposite has decreased motor deficit and improved grip strength significantly, especially at ND3 dose. Values are expressed as mean ± S.E.M. Results on comparison with the control group shows a significant difference (***p < 0.001). Results obtained shows significant difference from ischemic group (^#p < 0.05, ^###p < 0.001).