Experimental results of the continuous flow reaction at different residence time and temperaturesa.
| ||||
|---|---|---|---|---|
| Entry | Temp. (°C) | Res. time (min) | Product (%) | |
| 1 | 2 | |||
| 1 | 40 | 30 | 3.2 | 92.2 |
| 2 | 105 | 30 | 2.7 | 89.3 |
| 3 | 105 | 15 | 1.4 | 93.5 |
| 4 | 105 | 7.5 | 0.5 | 96.3 |
| 5 | 65 | 15 | 0.3 | 98.8 |
General reaction conditions: 2.04 M substrate, 0.1 M thiourea, 40–105 °C, 16 mL PFA reactor with 1.0 mm internal diameter and 1.6 mm external diameter.