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. 2020 Jan 16;10(5):2490–2494. doi: 10.1039/c9ra09119j

Experimental results of the continuous flow reaction at different residence time and temperaturesa.

graphic file with name c9ra09119j-u2.jpg
Entry Temp. (°C) Res. time (min) Product (%)
1 2
1 40 30 3.2 92.2
2 105 30 2.7 89.3
3 105 15 1.4 93.5
4 105 7.5 0.5 96.3
5 65 15 0.3 98.8
a

General reaction conditions: 2.04 M substrate, 0.1 M thiourea, 40–105 °C, 16 mL PFA reactor with 1.0 mm internal diameter and 1.6 mm external diameter.