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. 2022 Apr 25;10:e13135. doi: 10.7717/peerj.13135

Table 1. Topological properties of PPI network (top 20).

The top 20 proteins ranked from the most to the least significant P values for degree, betweenness and closeness.

Degree Betweenness Closeness
GNG10 46 THBS1 29293.018 FN1 0.008001986
MCHR1 36 LCK 23501.773 LCK 0.008000701
LPAR5 35 FN1 21341.697 ITGB3 0.007992882
CXCL1 33 GNG10 20834.193 PDGFB 0.007991134
PSMB8 31 VAMP8 20095.35 PTPN6 0.007990668
AGTR1 30 CXCL8 19591.28 IRS1 0.007990086
ADCY5 28 PLAU 19487.12 VAMP8 0.007989853
CXCL12 28 ITGB3 19444.19 PLAU 0.007989386
FN1 28 SNAP25 18873.1 STAT5A 0.007987756
CXCL8 27 PSMB8 16777.959 THBS1 0.007984032
THBS1 26 CXCL12 15816.917 CXCL12 0.007983218
GPR37 24 HIST2H2BE 15608.454 SERPINE1 0.007981357
NPBWR1 24 HIST1H2AC 13979.287 IGF2 0.007980079
ADRA2A 24 TWISTNB 13411.671 CXCL8 0.007979614
CXCL2 24 IRS1 13227.699 TGFB1 0.007979614
CXCL10 24 PTPN6 12547.569 KDR 0.007977988
NPY 24 GAD2 12330 SIRPA 0.007977756
CCL20 24 DIS3 11803.323 HLA-DRB5 0.007977291
IRF7 24 AGTR1 11732.014 HLA-DPB1 0.007977291
GAL 24 ALDH1A3 11584 PSMB8 0.007977059