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. 2022 Apr 14;13:876174. doi: 10.3389/fmicb.2022.876174

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Copyright © 2022 Zhang and An.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagrams of unique type III adaptation preference with (A) and without (B) reverse transcriptase activity. (A) RT represents reverse transcriptase, which is usually fused with Cas1–Cas2 complex, and may also be independent as well. Complementary DNA (cDNA) is depicted by blue. RNA template is depicted by pink, and the dashed lines represents potential digestion against the RNA template. (B) Single-stranded DNA (ssDNA) secondary structure is depicted by red. Hypothetical proteins or other elements are presented by white balls.