FIGURE 9.

Model of potential consequences of ΔTbD1 disrupted copper homeostasis under hypoxia. The module suggests that the TbD1 locus mediates a hypoxia-specific copper response via translocation of an unidentified copper chaperone (purple hexagon) across the cytoplasmic membrane. The chaperone then transports copper ions into the cytoplasm with subsequent protein–protein interaction between the chaperone-copper complex and RicR/CsoR, allowing the expression of downstream proteins and promoting adaptive changes in intracellular copper homeostasis.