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. 2022 Apr 12;13:845795. doi: 10.3389/fmicb.2022.845795

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Copyright © 2022 Kwon, Quan, Song, Chung, Jung, Hong, Na and Seok.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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DEX/lipo significantly reduces the pro-inflammatory cytokines and chemokines in mice with lethal influenza virus infection (A–E). Analysis of the inflammatory cytokines and chemokines collected from BALF of mock or influenza A virus infected mice treated with PBS/lipo, DEX, or DEX/lipo (n = 4–5 per group) on day 2 post-infection. TNFα (A), IL-1β (B), IL-6 (C), CXCL-1 (D), and CXCL2 (E) were measured by the enzyme-linked immunosorbent assay (ELISA). Data are presented as the means ± SEM and are representative of two independent experiments. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 by the one-way ANOVA test.