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A. Structures of UNC6212 (Kme2, orange), UNC6349 ( Ket2, pink), and UNC6864 (Kei, purple) peptide-based ligands. All ligands share the same scaffold and vary only in the alkylation on lysine. B. Aromatic residues (Y20, W41, and F44) in the CBX5 chromodomain aromatic cage bound to a H3K9me3 histone peptide (PDB: 3FDT).26 Y20 (green) and F44 (blue) were targeted in this study.
