Table 3.
Changes in echocardiographic parameters for left heart morphology and function before and after beraprost sodium administration.
| Variables | BPS 5 μg/kg | BPS 15 μg/kg | BPS 25 μg/kg | |||
|---|---|---|---|---|---|---|
| Pre | Post | Pre | Post | Pre | Post | |
| LA/Ao | 1.0 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.1 | 1.1 ± 0.0 | 1.0 ± 0.1 | 1.1 ± 0.1 |
| LVIDDN (cm/kg0.297) | 1.6 ± 0.1 | 1.6 ± 0.1 | 1.6 ± 0.1 | 1.6 ± 0.2 | 1.6 ± 0.1 | 1.5 ± 0.1 |
| LVIDSN (cm/kg0.315) | 1.0 ± 0.1 | 1.0 ± 0.1 | 1.0 ± 0.1 | 0.9 ± 0.2 | 0.9 ± 0.2 | 0.9 ± 0.2 |
| FS (%) | 38.3 ± 4.6 | 37.5 ± 4.6 | 35.6 ± 6.3 | 37.6 ± 11.4 | 40.3 ± 7.5 | 40.9 ± 7.4 |
| LVEDVI (mL/m2) | 65.7 ± 7.4 | 64.1 ± 7.3 | 71.1 ± 11.8 | 71.7 ± 9.6 | 70.2 ± 12.4 | 70.5 ± 9.7 |
| LVESVI (mL/m2) | 35.0 ± 6.1 | 33.0 ± 6.3 | 37.2 ± 5.7 | 34.2 ± 5.3 | 36.3 ± 7.5 | 33.0 ± 6.6* |
| EF (%) | 46.7 ± 6.8 | 48.8 ± 6.1 | 47.2 ± 2.4 | 52.6 ± 2.9* | 48.1 ± 3.8 | 53.3 ± 4.2* |
| LV SV (mL/m2) | 39.4 ± 7.6 | 40.9 ± 7.3 | 37.7 ± 4.9 | 46.4 ± 5.6* | 43.1 ± 6.8 | 48.3 ± 11.1* |
| LV CO (L/min/m2) | 3.8 ± 0.7 | 3.9 ± 0.7 | 3.3 ± 0.5 | 4.5 ± 0.7* | 4.1 ± 0.6 | 4.7 ± 1.1 |
| LV-SL (%) | 13.8 ± 0.9 | 13.7 ± 1.2 | 13.5 ± 1.7 | 14.7 ± 2.0 | 14.4 ± 2.3 | 14.5 ± 1.8 |
| LV-SrL (%/s) | 1.6 ± 0.2 | 1.5 ± 0.2 | 1.4 ± 0.2 | 1.5 ± 0.2 | 1.6 ± 0.4 | 1.6 ± 0.2 |
| LV-SC (%) | 19.1 ± 1.7 | 19.0 ± 1.5 | 16.6 ± 2.4 | 18.8 ± 1.8* | 19.2 ± 3.1 | 20.4 ± 1.3 |
| LV-SrC (%/s) | 1.9 ± 0.2 | 1.9 ± 0.2 | 1.7 ± 0.2 | 1.9 ± 0.2* | 2.0 ± 0.4 | 2.0 ± 0.1 |
BPS, beraprost sodium; COI, cardiac output normalized by body surface area; EF, ejection fraction; LA/Ao, left atrium to aortic diameter ratio; LV, left ventricular; LVEDVI, end-diastolic left ventricular volume normalized by body surface area; LVESVI, end-systolic left ventricular volume normalized by body surface area; LVIDDN, end-diastolic left ventricular internal dimension normalized by body weight; LVIDSN, end-systolic left ventricular internal dimension normalized by body weight; LV-SC; left ventricular circumferential strain; LV-SL, LV longitudinal strain; LV-SrC, LV circumferential strain rate; LV-SrL, LV longitudinal strain rate; SVI, stroke volume normalized by body surface area.
Continuous variables were displayed as mean ± standard deviation.
The value is significantly different from pre-examination of the corresponding dose of BPS (p < 0.050).