FIGURE 3.

Depiction of biofilm removal using phages and its derived enzymes. (1). Bacteriophage therapy, consisting of single phage therapy and cocktail therapy, that is used for intra- to extracellular degradation of the bacterial structure. (2). Phage-derived endolysin used for extra- to intracellular degradation of the bacterial structure. (3). Phage-derived depolymerase, presented as free enzyme or tail spike protein, that is used for chemical dispersion of the biofilm matrix. (4). Combination therapy using both phages and other antimicrobial compounds, such as antibiotics. (5). Genetically-modified phages that enlarge the host-species interaction range.