TABLE 3.
Results of testing BMS 284756 and 15 comparison orally administered agents against 88 M. catarrhalis strains isolated from SENTRY Antimicrobial Surveillance Program sites in Latin America, 1999
| Antimicrobial agent | MIC (μg/ml)
|
% Susceptibilea | ||
|---|---|---|---|---|
| 50% | 90% | Range | ||
| BMS 284756 | ≤0.03 | ≤0.03 | ≤0.03–0.12 | 100.0 (≤4) |
| Ciprofloxacin | 0.03 | 0.03 | ≤0.015–0.25 | 100.0 (≤1) |
| Gatifloxacin | ≤0.03 | ≤0.03 | ≤0.03–0.25 | 100.0 (≤0.5) |
| Levofloxacin | ≤0.03 | 0.06 | ≤0.03–0.5 | 100.0 (≤2) |
| Trovafloxacin | ≤0.03 | ≤0.03 | ≤0.03–0.25 | 100.0 (≤1) |
| Penicillin | 4 | >4 | ≤0.03–>4 | 1.1 (BL) |
| Amoxicillin-clavulanate | ≤0.25 | ≤0.25 | ≤0.25 | 100.0 (≤2) |
| Cefaclor | 0.5 | 1 | ≤0.25–8 | 100.0 (≤8) |
| Cefuroxime | 1 | 2 | ≤0.06–4 | 100.0 (≤4) |
| Cefixime | 0.12 | 0.25 | ≤0.03–2 | 98.9 (≤1) |
| Cefpodoxime | 0.5 | 1 | 0.06–1 | 100.0 (≤2) |
| Erythromycin | ≤0.25 | ≤0.25 | ≤0.25–4 | 98.9 (≤0.5) |
| Chloramphenicol | ≤2 | ≤2 | ≤2–4 | 100.0 (≤4) |
| Tetracycline | ≤2 | ≤2 | ≤2 | 100.0 (≤2) |
| Trimethoprim-sulfamethoxazole | ≤0.5 | ≤0.5 | ≤0.5–2 | 97.7 (≤0.5) |
| Rifampin | ≤1 | ≤1 | ≤1 | 100.0 (≤1) |
a
Susceptibility criteria have not been published for this species (6). β-Lactamase (BL) production indicated resistance for penicillins, and other drugs were judged according to the criteria in parentheses.