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. 2022 Apr 13;29(1):1243–1256. doi: 10.1080/10717544.2022.2063454

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Analysis of Fv-LDP-D3 and Fv-LDP-D3-AE bioactivity. (A) Fv-LDP-D3-induced inhibition of KYSE150, KYSE520, and Eca109 cell proliferation, as determined by CCK8 assay. (B) EGFR and IMPDH2 expression in different esophageal cancer cell lines were determined by western blot analysis. (C) Western blot analysis of EGFR and IMPDH2 expression in KYSE150 and KYSE520 cells treated with Fv-LDP-D3 for 24 h. (D) The cytotoxicity effects of Fv-LDP-D3-AE in different esophageal cancer cell lines were evaluated by CCK8 assays. (E) KYSE150 and Eca109 cells were treated with different concentrations of Fv-LDP-D3-AE for 24 h. Western blot analysis of EGFR and phosphor-EGFR expression. (F,G) The effect of Fv-LDP-D3-AE on the proliferation of KYSE150 and Eca109 cells was determined by EdU staining assays (Photo multiple, ×200). Results are reported as means ± standard deviation (SD) (n = 3). NS: no significance, *p < 0.05, **p < 0.01, ***p < 0.001 versus control group.