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. 2022 Apr 13;29(1):1243–1256. doi: 10.1080/10717544.2022.2063454

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 8. — In vivo therapeutic efficacy. (A) Tumor growth curve of the KYSE150 tumor xenograft model (n = 6). Mice were treated with Fv-LDP-D3-AE (0.2 mg/kg). (B) Body weight growth curve of ESCC KYSE150 tumor xenograft models. KYSE520 xenograft mice were treated with various doses of Fv-LDP-D3 (20, 40 mg/kg), Fv-LDP-D3-AE (0.25, 0.50 mg/kg). (C) Tumor growth curves. (D) Tumor weights at the end of the experiment. (E) Body weight change curves, and (F) Immunohistochemical detection of Ki-67. *p < 0.05, **p < 0.01, ***p < 0.001 compared with the control.