The effects of 8 consecutive-week administration of PES14 on the blood biochemical indexes of the diabetic mice. All data are expressed as means ± SD (n = 8). *P < 0.05, **P < 0.02, ***P < 0.001 vs. saline group.
| Parameters | Saline | Semaglutide | PES14 (10 nM kg−1) | PES14 (30 nM kg−1) | PES14 (90 nM kg−1) |
|---|---|---|---|---|---|
| TG (mmol L−1) | 1.2 ± 0.4 | 0.9 ± 0.3* | 1.1 ± 0.1 | 1.0 ± 0.7 | 0.8 ± 0.5 |
| TC (mmol L−1) | 5.0 ± 0.7 | 4.3 ± 0.2* | 4.8 ± 0.6 | 4.4 ± 0.3* | 3.7 ± 0.4** |
| LDL (mmol L−1) | 1.7 ± 0.2 | 1.1 ± 0.4** | 1.6 ± 0.3 | 1.4 ± 0.2 | 1.0 ± 0.3** |
| HDL (mmol L−1) | 2.3 ± 0.7 | 2.4 ± 0.5 | 2.5 ± 0.6 | 2.5 ± 0.5 | 2.7 ± 0.3 |
| LDL/HDL | 0.66 ± 0.10 | 0.45 ± 0.18** | 0.64 ± 0.19 | 0.44 ± 0.15** | 0.35 ± 0.13*** |
| ALT (IU L−1) | 61.9 ± 4.4 | 44.1 ± 3.1** | 59.2 ± 2.8 | 55.0 ± 4.0 | 45.0 ± 3.5** |
| AST (IU L−1) | 162 ± 10.6 | 130 ± 6.9** | 158 ± 12.2 | 140 ± 9.9* | 126 ± 8.5** |