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Roles cfDNA Plays in OLP. cfDNA in OLP is recognized by DNA sensors in immune cells and keratinocytes, leading to the activation of STING and production of pro-inflammatory cytokines associated with activated T lymphocytes. CD8+ T lymphocytes induce keratinocytes apoptosis by releasing cytotoxins. Apoptotic and dead cells release cfDNA, which further promotes inflammation in OLP, leading to a positive feedback cycle.
