Table 3.
Diagnostic Accuracies of POSITVE, PREDICT, and VIRSTA Scores
| Score | Sensitivity (% + 95% CI) | Specificity (% + 95% CI) | Negative Predictive Value (% + 95% CI) | Positive Predictive Value (% + 95% CI) | AUC |
|---|---|---|---|---|---|
| POSITIVEa | 77.6 (65.8–86.9) | 63.1 (57.3–68.6) | 92.5 (87.9–95.8) | 32.3 (25.1–40.1) | 77.8 (71.9–83.7) |
| PREDICT day 1 | 22.9 (14.6–33.5) | 97.4 (95.3–98.8) | 85.0 (81.4–88.2) | 66.7 (47.2–82.7) | 71.4 (65.2–77.5) |
| PREDICT day 5 | 85.1 (75.8–91.8) | 56.9 (51.8–61.9) | 94.5 (90.7–97.0) | 30.5 (24.7–36.8) | 79.7 (73.9–85.4) |
| VIRSTA | 98.9 (95.7–100) | 35.7 (30.8–40.6) | 99.3 (94.9–100) | 25.5 (20.7–30.3) | 88.9 (85.3–92.5) |
Abbreviations: AUC, area under the receiver operating characteristic curve; CI, confidence interval.
aPOSITIVE score was calculated on the TTP cohort of 362 patients.