TABLE 1.

Concentrations of total ciprofloxacin in blood at various intervals after i.v. administration of PL Cipro or CIP in rats with K. pneumoniae lung infection^a

Time after treatment	Concn (μg/ml) (% of injected dose) of ciprofloxacin in blood after treatment with:
	PL Ciprob	CIPc
3 min		17.6 ± 1.6 (4.7)
10 min		8.6 ± 2.1 (2.3)
30 min	291 ± 32 (77)	5.0 ± 1.2 (1.3)
1 h	212 ± 30 (56)	3.3 ± 1.1 (0.9)
3 h	97 ± 7.5 (26)
6 h	35 ± 7.0 (9.2)

^aPL Cipro (20 mg/kg; total lipid, 86 μmol/kg) or CIP (20 mg/kg) was injected as a single dose into rats at 24 h after inoculation of K. pneumoniae in the left lung. Total (CIP plus PL Cipro) concentrations of ciprofloxacin are presented. Data are expressed as mean ± SD six rats. 

^bAUC_0–6h was 800 μg · h/ml. 

^cAUC_0–1h was 15.8 μg · h/ml.