TABLE 1.
Time after treatment | Concn (μg/ml) (% of injected dose) of ciprofloxacin in blood after treatment with:
|
|
---|---|---|
PL Ciprob | CIPc | |
3 min | 17.6 ± 1.6 (4.7) | |
10 min | 8.6 ± 2.1 (2.3) | |
30 min | 291 ± 32 (77) | 5.0 ± 1.2 (1.3) |
1 h | 212 ± 30 (56) | 3.3 ± 1.1 (0.9) |
3 h | 97 ± 7.5 (26) | |
6 h | 35 ± 7.0 (9.2) |
PL Cipro (20 mg/kg; total lipid, 86 μmol/kg) or CIP (20 mg/kg) was injected as a single dose into rats at 24 h after inoculation of K. pneumoniae in the left lung. Total (CIP plus PL Cipro) concentrations of ciprofloxacin are presented. Data are expressed as mean ± SD six rats.
AUC0–6h was 800 μg · h/ml.
AUC0–1h was 15.8 μg · h/ml.