TABLE 2.
Therapeutic efficacy of treatment of rats with K. pneumoniae lung infectiona
| Dosage (mg/kg/day)b | No. of surviving rats/total no. of rats receiving treatment
|
||
|---|---|---|---|
| CIP twice daily | CIP once daily | PL Cipro once daily | |
| 80 | 8/8c | ||
| 40 | 15/15 | 4/8 | 8/8 |
| 20 | 9/10 | 5/8 | 8/8 |
| 10 | 7/10 | 2/8 | 7/8 |
| 5 | 5/10 | 2/8 | 3/8 |
| 2.5 | 2/10 | 0/8 | 3/8 |
| 1.25 | 2/10 | 3/8 | |
| 0.6 | |||
| 0.3 | 0/5 | ||
| ED50 | 5.1 (2.6–8.6) | 18.9 (10.5–37.0) | 3.3 (1.7–5.7) |
| ED90 | 36.0 (18.3–164) | >MTD | 15.0 (8.0–78.9) |
a
Treatment was started at 24 h after inoculation of K. pneumoniae in the lung and continued for 3 days. Survival of rats was assessed for a period of 21 days. Untreated rats died before day 6 after inoculation.
b
ED50s and ED90s are expressed as milligrams per kilograms per day. Values in parentheses are 95% confidence intervals.
c
Toxic side effects (acute toxicity) were observed in four out of eight rats.