Scheme 5. General synthesis of 2-((bis(trimethylsilyl) methylthio/methylsulfonyl) methyl)-5-aryl-1,3,4-oxadiazoles. Reagents and conditions: (a) HSCH2COOH, MeOH, NaOH, reflux 4 h; (b) H2O2, AcOH, 24 h; (c) ArCONHNH2, POCl3, reflux 6 h.
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