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. 2022 Apr 28;17(4):e0267856. doi: 10.1371/journal.pone.0267856

Table 1. Demographics of study population according to time from emergency department visit to emergency neurosurgery.

Time from ED visit to neurosurgery
Total Ultra-early (0–2 hours) Early (2–4 hours) Late (4–12 hours) p-value
N (%) N (%) N (%) N (%)
Total 2,602 525 (20.2) 1,093 (42.0) 984 (37.8)
Age, year, median (IQR) 61 (51–73) 61 (51–71) 61 (51–74) 61 (52–73) 0.71
 0–49 562 (21.6) 116 (22.1) 252 (23.1) 194 (19.7) 0.48
 50–59 649 (24.9) 134 (25.5) 260 (23.8) 255 (25.9)
 60–69 568 (21.8) 120 (22.9) 226 (20.7) 222 (22.6)
 70–79 538 (20.7) 106 (20.2) 224 (20.5) 208 (21.1)
 80–120 285 (11.0) 49 (9.3) 131 (12.0) 105 (10.7)
Sex, male 1,341 (51.5) 268 (51.0) 552 (50.5) 521 (52.9) 0.52
EMS use 1,670 (64.2) 330 (62.9) 703 (64.3) 637 (64.7) <0.01
Transferred from other hospital 789 (30.3) 172 (32.8) 339 (31.0) 278 (28.3) 0.16
Level 1 ED 1,185 (45.5) 251 (47.8) 513 (46.9) 421 (42.8) 0.08
Time of ED visit <0.01
 MN–8AM 482 (18.5) 84 (16.0) 182 (16.7) 216 (22.0)
 8AM–4PM 1,138 (43.7) 220 (41.9) 462 (42.3) 456 (46.3)
 4PM–MN 982 (37.7) 221 (42.1) 449 (41.1) 312 (31.7)
Mental status at triage <0.01
 Alert 627 (24.1) 82 (15.6) 256 (23.4) 289 (29.4)
 Verbal response 500 (19.2) 85 (16.2) 216 (19.8) 199 (20.2)
 Pain response 1,114 (42.8) 257 (49.0) 483 (44.2) 374 (38.0)
 Unresponsive 361 (13.9) 101 (19.2) 138 (12.6) 122 (12.4)
Hemorrhagic stroke <0.01
 SAH 411 (15.8) 45 (8.6) 155 (14.2) 211 (21.4)
 ICH 2,044 (78.6) 460 (87.6) 879 (80.4) 705 (71.6)
 Mixed 147 (5.6) 20 (3.8) 59 (5.4) 68 (6.9)
Combined IVH 701 (26.9) 187 (35.6) 309 (28.3) 205 (20.8) <0.01
Type of neurosurgery <0.01
 Burr-hole, in ED 226 (8.7) 83 (15.8) 111 (10.2) 32 (3.3)
 Burr-hole, in operation room 1,250 (48.0) 248 (47.2) 556 (50.9) 446 (45.3)
 Other neurosurgery 1,126 (43.3) 194 (37.0) 426 (39.0) 506 (51.4)
ED disposition <0.01
 ICU admission 500 (19.2) 94 (17.9) 141 (12.9) 265 (26.9)
 Operation room 2,048 (78.7) 423 (80.6) 923 (84.4) 702 (71.3)
Reoperation 332 (12.8) 61 (11.6) 136 (12.4) 135 (13.7) 0.47
In-hospital mortality 639 (24.6) 139 (26.5) 243 (22.2) 257 (26.1) 0.06

ED, emergency department; IQR, interquartile range; EMS, emergency medical services; SAH, subarachnoid hemorrhage; ICH, intracerebral hemorrhage; IVH, intraventricular hemorrhage; ICU, intensive care unit.