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. 2020 Feb 4;10(10):5610–5635. doi: 10.1039/c9ra09510a

List of some of the 1,2,3-triazole linked pharmacophore molecules possessing anti-Alzheimer's activity as observed using IC50 values.

Sr. no. Parent compound Biological target IC50 (μM) Reference
74 graphic file with name c9ra09510a-u74.jpg BACE1 2.0 117
75 graphic file with name c9ra09510a-u75.jpg AChE 2.000 ± 0.030 119
BChE 1.55 ± 0.012
76 graphic file with name c9ra09510a-u76.jpg 42 aggregation 8.065 ± 0.129 120
77 graphic file with name c9ra09510a-u77.jpg BACE1 2.2 121
78 graphic file with name c9ra09510a-u78.jpg Acetylcholinesterase 1.80 122
79 graphic file with name c9ra09510a-u79.jpg (a) 123
AChEI 0.027 ± 0.009
BChEI 0.104 ± 0.018
(b)
AChEI 0.095 ± 0.014
BChEI 0.006 ± 0.002