List of some of the 1,2,3-triazole linked pharmacophore molecules possessing anti-Alzheimer's activity as observed using IC50 values.
Sr. no. | Parent compound | Biological target | IC50 (μM) | Reference |
---|---|---|---|---|
74 | BACE1 | 2.0 | 117 | |
75 | AChE | 2.000 ± 0.030 | 119 | |
BChE | 1.55 ± 0.012 | |||
76 | Aβ42 aggregation | 8.065 ± 0.129 | 120 | |
77 | BACE1 | 2.2 | 121 | |
78 | Acetylcholinesterase | 1.80 | 122 | |
79 | (a) | 123 | ||
AChEI | 0.027 ± 0.009 | |||
BChEI | 0.104 ± 0.018 | |||
(b) | ||||
AChEI | 0.095 ± 0.014 | |||
BChEI | 0.006 ± 0.002 |