TABLE 1.
Susceptibility of H. pylori strains to clarithromycin and detection of 23S rDNA mutations by PCR-LiPA in six laboratories
| Laboratory location | Macrolide susceptibility as determined by agar dilution or E-test | No. of strains with indicated 23S rDNA status determined by PCR-LiPA
|
Total | |
|---|---|---|---|---|
| Wild type | Mutant | |||
| The Netherlands (n = 51) | Susceptible | 28 | 2a | 30 |
| Resistant | 1 | 20 | 21 | |
| France (n = 52) | Susceptible | 26 | 26 | |
| Resistant | 2 | 24 | 26 | |
| Australia (n = 56) | Susceptible | 34 | 34 | |
| Resistant | 22 | 22 | ||
| Belgium (n = 51) | Susceptible | 26 | 26 | |
| Resistant | 25 | 25 | ||
| Switzerland (n = 37) | Susceptible | 19 | 19 | |
| Resistant | 18 | 18 | ||
| Brazil (n = 52) | Susceptible | 34 | 34 | |
| Resistant | 18 | 18 | ||
| Total (n = 299) | 170 | 129 | 299 | |
a
Contained a mixture of wild-type and A2143G mutant sequences, and the MICs were shown to vary during retesting.