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. 2022 Apr 14;13:869544. doi: 10.3389/fpsyt.2022.869544

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Copyright © 2022 Liu, Li, Huang, Cao, Cai, Guo, Wang, Zhao, Wang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Establishment of paclitaxel chemotherapy pain model. (A,B) The behavioral changes of paw withdrawal thresholds and paw withdrawal latencies in the vehicle group and paclitaxel group at different time. (C) Open field test trajectory diagram of vehicle and paclitaxel groups. (D) Total distance statistics of the vehicle group and paclitaxel group. (E) The statistical results of the percentage of central area activity time in the vehicle group and paclitaxel group. (F) The trajectory diagram of the elevated plus maze test in the vehicle and paclitaxel groups. (G) Statistic results of the percentage of open arm entry time in the vehicle group and paclitaxel group. (H) Statistic results of the number of entries open arm in the vehicle group and paclitaxel group. n = 6–9, ns, no significant, *P < 0.05, **P < 0.01, ***P < 0.001.