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. 2022 Apr 14;13:869544. doi: 10.3389/fpsyt.2022.869544

Figure 4.

Figure 4

Selectively inhibiting CaMKII neurons in the BLA relieves paclitaxel-induced pain. (A) Timeline of virus injection, Clozapine-N-oxide (CNO) administration, and experiments and the Schematic diagram of virus injection site. (B) Representative imaging of hM3Dq virus expression within CaMKII neurons in the BLA 3 weeks after viral injection. Scale bars = 100 μm. (C) Representative imaging of hM3Dq virus expression within CaMKII neurons in the BLA 3 weeks after viral injection. Under high magnification co-labeled of hM3Dq-mCherry (red) and CaMKII (green), and co-labeled of hM3Dq-mCherry (red) and Fos (green). Scale bars = 50 μm. (D) The percentage of the numbers of hM3Dq and Fos co-labeled neurons to hM3Dq labeled neurons in EYFP and hM3Dq. (E) Changes in PWT after activation or inhibition of CaMKII neurons. (F) Changes in PWL after activation or inhibition of CaMKII neurons. n = 6–7, ns, no significant, **P < 0.01, ***P < 0.001.