Fig. 5. Comparison between binding sites of compound 5 within crystal structure of PIM-1 (PDB code 3 UMW), PIM-2 (PDB code 4X7Q) and modeled PIM-3. (A and B) active site of PIM-1 shows some hydrogen bonding and hydrophobic interaction with important active site residues. (C and D) Small hydrophobic active site of PIM-2 have Leu 38, Val 46, and Ile 141. All of these residues are conserved in PIM-1. (E and F) Binding site of PIM-3 also contains some hydrophobic residues.
