Fig. 4. (A andB) BMP-9 overexpression promoted the tumor growth of A549 (A) and NCl-H1650 (B) xenograft in nude mice. (C) BMP-9 overexpression up-regulated p-Smad1/5 level and PI3K/Akt pathway of A549 and NCl-H1650 xenograft in nude mice. (D and E) Knockdown BMP-9 or ALK1 suppressed the tumor growth of A549 (D) and NCl-H1650 (E) xenograft in nude mice. (F) Knockdown BMP-9 or ALK1 suppressed p-Smad1/5 level and PI3K/Akt pathway of A549 and NCl-H1650 xenograft in nude mice. Data were represented as the mean ± SEM, #p < 0.05 versus AdGFP or Sh-Con group, ##p < 0.01 versus AdGFP or Sh-Con group.
